Science & Technology
PolyXen

Here are a number of key scientific publications featuring our PolyXen technology.  They can be downloaded as PDFs by clicking on the links below.

Polysialic Acids: A New Generation of Polymers for Peptide and Protein Delivery
Size: 3233kb

Controlled Release Society Newsletter, 22(3):14-16, 2005

Polysialylation: The New Way.
Size: 3597kb

European Biopharmaceutical Review, Winter 2005: 94-101, 2005

Improving the therapeutic efficacy of peptides and proteins: A role for polysialic acids.
Size: 201kb

International J.of Pharmaceutics, 300, 125-130, 2005.

Polysialylation: The natural way to improve the stability and pharmacokinetics of protein and peptide drugs.
Size: 3380kb

Drug Delivery Systems and Sciences, 4 (No 1): 3-9, 2004.

Improving the pharmacokinetics of protein and peptide drugs: Nature's way,
Size: 258kb

The Drug Delivery Companies Report, pp. 44-47, Autumn/Winter 2003

Polysialylated insulin: Synthesis, characterization and biological activity in vivo
Size: 551kb

Biochim.Biophys.Acta, 1622:42-49, 2003

The effect of polysialylation on the immunogenicity and antigenicity of asparaginase: Implications in its pharmacokinetics
Size: 107kb

Int. J. Pharmaceutics, 217: 215-224, 2001

Polysialic acids: Potential in improving the stability and pharmacokinetics of proteins and other therapeutics
Size: 1718kb

CMLS Cellular and Molecular Life Sciences, 57: 1964-1969, 2000

Polysialylated proteins: An approach to improving enzyme stability and half-life in the blood circulation
Size: 4644kb

S.T.P. Pharma Sciences 9: 61-66, 1999

Polysialylated asparaginase: Preparation, activity and pharmacokinetics
Size: 512kb

Biochim.Biophys.Acta, 1341: 26-34, 1997

Synthesis, characterization and properties of polysialylated catalase
Size: 2825kb

Biochim.Biophys.Acta, 1293: 92-96, 1996

Polysialic acids: Potential in drug delivery
Size: 610kb

FEBS Lett., 315:271-276, 1993